REBIRTH Hannover

Forschungsfelder

Kernprojekte und Synergyprojekte

Die PIs (Principle Investigator) von REBIRTH verfolgen Ihre Forschungsaktivitäten mithilfe unterschiedlichster Förderungen.

Einige werden durch die REBIRTH-Nachhaltigkeitsfinanzierung des Niedersächsischen Ministeriums für Wissenschaft und Kunst ermöglicht.

Jene Projekte finden sich unter REBIRTH Forschungsprojekte.

Zudem sind die PIs an einer Reihe von Forschungsverbünden und Netzwerken beteiligt. Der Link auf die entsprechenden Homepages finden Sie hier Forschungsverbünde.

Alpharetroviral-mediated cell modification for regenerative gene therapy


Bio-VAD – Biologization of left ventricular assist devices for improved hemocompatibility and extended clinical application


Creating and exploiting regulatory macrophages for tissue repair


Cytogenetic integrity of genetically modified cells


ELexIR: Embedded Legal and Ethics Intelligence in REBIRTH


Engineering of on-chip functional 3D microvessels using optogenetics and microfluidics


Genetic integrity of genetically modified cells


Genetically enhanced iPSC-derived macrophages (iMAC) for regenerative and corrective gene and cell therapy


Induced Pluripotent Stem Cell-Derived Hepatobiliary Organoids for Studies of Disease Mechanisms and Gene Engineering Approaches


iPSC-derived cardiac μ-tissue for Clinical Heart Repair

and


Next generation noncoding RNA therapeutics for cardiac healing


Optimizing liver-directed in vivo gene therapy


Role of mutations in DNA Damage Response genes for physiological and pathophysiological cardiac stress and the regeneration potential of the heart


Safety and efficacy of next generation gene therapy tools for hereditary liver diseases


Scaffold optimization and small molecule drugs for iPSC based heart repair and disease modellin

and


Secretome-Based Therapy to Target Organ (Cardiac and Lung) Fibrosis


Swapping the Pulmonary Immunity (SwaPI) to regenerate a dysfunctional alveolar macrophage cell pool


Systems-Based Molecular Imaging of Regenerative Mechanisms


Targeted delivery of biologics and small molecule drugs for tissue regeneration

and

and


Targeted delivery of biologics and small molecule drugs for tissue regeneration

and


Targeted delivery of biologics and small molecule drugs for tissue regeneration

and


Transprogramming and regeneration to overcome liver failure


Screening of Telomerase Stimulators for Cardiac Regeneration & Repair (CR&R) by Cell Microarrays

and


Building and breaking the wall: Engineering small and leaky blood vessels

and

and


Artificial bone marrow niche for iPSC-based in vitro modeling of engraftment and maintenance of hematopoietic stem cells

and


Interplay between heart failure (HF) and dementia: from molecular mechanisms to therapeutic intervention.

and


Investigation of the regenerative potential of compounds identified in a high-throughput screening in in vitro and in vivo models of Parkinson’s disease

and


Developing nucleus-targeting nanoparticles as a modality for enhancing the efficiency of direct lineage reprogramming

and


Mimicking and manipulating stem cell niche mediated regeneration in animal-free experiments via organoids and organ-on-a-chip techniques

and


Regenerative processes in chronic obstructive lung diseases

and


Towards better understanding and manipulation of tissue-resident αβ and γδ T lymphocytes in human lung tissue and lung-draining lymph nodes during end-stage lung diseases

and


Generating immunomodulatory macrophages for tissue repair and regeneration

and


Analysis of cellular repair mechanisms and in vivo regeneration of the liver using optical techniques

and


Automated human iPSC macrophage production platform (iMAPP) for drug screening and tissue regeneration

and


Function of non-coding RNAs in Hepatic Stellate Cells during liver regeneration          

and


Maximizing Kidney Regeneration by Reparative Cellular Senescence Reprogramming


Investigation of astrocyte-microglia cross-talk during regeneration in the central nervous system

and


Imaging the Interface of Inflammation and Fibrosis in Progression and Treatment of Acute Myocardial Infarction and Ischemic Heart Failure: Molecular Imaging-Guided Precision Therapy

and


Role of TPC and TRPML channels for extracellular vesicles release from cardiac macrophages in cardiac tissue repair and regeneration


Biliary cells in liver regeneration and repair

and

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