REBIRTH Hannover
Core Projects and Synergy Projects
The PIs (Principle Investigators) of REBIRTH pursue their research activities with the help of a wide variety of funding.
Some are made possible by REBIRTH sustainability funding from the Lower Saxony Ministry of Science and the Arts.
Those projects can be found under REBIRTH Research Projects.
In addition, the PIs are involved in a number of research associations and networks. The link to the corresponding homepages can be found here: Research networks.
▼ Core Projects
Alpharetroviral-mediated cell modification for regenerative gene therapy
- PI(s): Dr. Dr. Axel Schambach
- Institute: Clinic for Pediatric Pneumology, Allergology and Neonatology (former: Exp. Hematology), MHH
Bio-VAD – Biologization of left ventricular assist devices for improved hemocompatibility and extended clinical application
- PI(s): Bettina Wiegmann
- Institute: Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG), MHH
Creating and exploiting regulatory macrophages for tissue repair
- PI(s): Dr. Reinhold Förster
- Institute: Institute of Immunology, MHH
Cytogenetic integrity of genetically modified cells
- PI(s): Dr. med. Gudrun Göhring
- Institute: Department of Human Genetics, MHH
ELexIR: Embedded Legal and Ethics Intelligence in REBIRTH
- PI(s): Dr. Nils Hoppe
- Institute: Centre for Ethics and Law in the Life Sciences (CELLS), LUH
Engineering of on-chip functional 3D microvessels using optogenetics and microfluidics
- PI(s): Dr. Alexander Heisterkamp
- Institute: Institute of Quantum Optics, LUH
Genetic integrity of genetically modified cells
- PI(s): Dr. rer. nat. Doris Steinemann
- Institute: Department of Human Genetics, MHH
Genetically enhanced iPSC-derived macrophages (iMAC) for regenerative and corrective gene and cell therapy
- PI(s): Dr. Thomas Moritz
- Institute: Clinic for Pediatric Pneumology, Allergology and Neonatology (former: Exp. Hematology), MHH
Induced Pluripotent Stem Cell-Derived Hepatobiliary Organoids for Studies of Disease Mechanisms and Gene Engineering Approaches
- PI(s): Dr. Tobias Cantz
- Institute: Department of Gastroenterology, Hepatology and Endocrinology, MHH
iPSC-derived cardiac μ-tissue for Clinical Heart Repair
- PI(s): Dr. Ina Gruh, Prof. Dr. Axel Haverich, Prof. Dr. Sergej Cebotari, Prof. Dr. Andreas Martens, Prof. Dr. Ulrich Martin, Dr. Robert Zweigerdt
- Institute: Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG)/
Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe (LEBAO), MHH
and
- PI(s): Dr. Danny Jonigk
- Institute: Pathology, MHH
Next generation noncoding RNA therapeutics for cardiac healing
- PI(s): Dr. Dr. Thomas Thum
- Institute: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), MHH
Optimizing liver-directed in vivo gene therapy
- PI(s): Dr. Hildegard Büning
- Institute: Clinic for Pediatric Pneumology, Allergology and Neonatology (former: Exp. Hematology)
Role of mutations in DNA Damage Response genes for physiological and pathophysiological cardiac stress and the regeneration potential of the heart
- PI(s): Dr. Denise Hilfiker-Kleiner
- Institute: Department of Cardiology und Angiology, MHH
Safety and efficacy of next generation gene therapy tools for hereditary liver diseases
- PI(s): Dr. Michael Ott
- Institute: Department of Gastroenterology, Hepatology and Endocrinology, MHH
Scaffold optimization and small molecule drugs for iPSC based heart repair and disease modellin
- PI(s): Gerald Dräger, Prof. Dr. Andreas Kirschning
- Institute: Institute of Organic chemistry, LUH
and
- PI(s): Dr. Ina Gruh
- Institute: Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG)/
Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe (LEBAO), MHH
Secretome-Based Therapy to Target Organ (Cardiac and Lung) Fibrosis
- PI(s): Dr. Kai Wollert
- Institute: Department of Cardiology und Angiology, MHH
Swapping the Pulmonary Immunity (SwaPI) to regenerate a dysfunctional alveolar macrophage cell pool
- PI(s): Dr. Nico Lachmann
- Institute: Clinic for Pediatric Pneumology, Allergology and Neonatology (former: Exp. Hematology)
Systems-Based Molecular Imaging of Regenerative Mechanisms
- PI(s): Dr. Frank Bengel
- Institute: Nuclear medicine, MHH
Targeted delivery of biologics and small molecule drugs for tissue regeneration
- PI(s): Andres Hilfiker
- Institute: Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG)/
Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe (LEBAO), MHH
and
- PI(s): Dr. Falk Büttner
- Institute: Institute of Clinical Biochemistry, MHH
and
- PI(s): Dr. Heiner Niemann
- Institute: Department of Gastroenterology, Hepatology and Endocrinology, MHH
(former: FLI-Mariensee)
Targeted delivery of biologics and small molecule drugs for tissue regeneration
- PI(s): Dr. Andreas Kirschning
- Institute: Institute of Organic Chemistry, LUH
and
- PI(s): Dr. Dagmar Wirth
- Institute: Helmhotz Centre for Infection Research (HZI)
Targeted delivery of biologics and small molecule drugs for tissue regeneration
- PI(s): Dr. Ulrich Martin
- Institute: Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG)/
Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe (LEBAO), MHH
and
- PI(s): Dr. Oliver Plettenburg
- Institute: Center of Biomolecular Drug Research (BMWZ), LUH
Transprogramming and regeneration to overcome liver failure
- PI(s): PD Dr. Amar Deep Sharma
- Institute: Department of Gastroenterology, Hepatology and Endocrinology, MHH
▼ Synergy Projects
Screening of Telomerase Stimulators for Cardiac Regeneration & Repair (CR&R) by Cell Microarrays
- PI(s): Prof. Dr. Christian Bär
- Institute: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), MHH
and
- PI(s): Dr. Carsten Zeilinger
- Institute: Center of Biomolecular Drug Research (BMWZ), LUH
Building and breaking the wall: Engineering small and leaky blood vessels
- PI(s): Dr. Ruth Olmer
- Institute: Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG)/
Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe (LEBAO), MHH
and
- PI(s): Prof. Dr. Cornelia Lee-Thedieck
- Institute: Institute of Physical Chemistry and Electrochemistry, LUH
and
- PI(s): Prof. Dr. Marie Weinhart
- Institute: Institute of Cell Biology and Biophysics, LUH
Artificial bone marrow niche for iPSC-based in vitro modeling of engraftment and maintenance of hematopoietic stem cells
- PI(s): Prof. Dr. Axel Schambach, PhD
- Institute: Clinic for Pediatric Pneumology, Allergology and Neonatology (former: Exp. Hematology), MHH
and
- PI(s): Prof. Dr. Cornelia Lee-Thedieck
- Institute of Physical Chemistry and Electrochemistry, LUH
Interplay between heart failure (HF) and dementia: from molecular mechanisms to therapeutic intervention.
- PI(s): Dr. Evgeni Ponimaskin
- Institute for Neurophysiology. MHH
and
- PI(s): Prof. Dr. Denise Hilfiker-Kleiner
- Institute: Department of Cardiology und Angiology, MHH
Investigation of the regenerative potential of compounds identified in a high-throughput screening in in vitro and in vivo models of Parkinson’s disease
- PI(s): Dr. Claudia Grothe
- Institute: Institute of Neuroanatomy and Cell Biology, MHH
and
- PI(s): Dr. Günther Höglinger / Dr. Matthias Höllerhage
- Institute: Clinic for Neurology. MHH
Developing nucleus-targeting nanoparticles as a modality for enhancing the efficiency of direct lineage reprogramming
- PI(s): PD Dr. Amar Sharma
- Institute: Department of Gastroenterology, Hepatology and Endocrinology, MHH
and
- PI(s): Annette Hoffmann
- Institute: Institute of Quantum Optics, LUH
Mimicking and manipulating stem cell niche mediated regeneration in animal-free experiments via organoids and organ-on-a-chip techniques
- PI(s): Prof. Dr. André Bleich, Dr. Manuela Büttner
- Institute: Animal Reserach, MHH
and
- PI(s): Prof. Dr. Alexander Heisterkamp
- Institute: Institute of Quantum Optics, LUH
Regenerative processes in chronic obstructive lung diseases
- PI(s): Prof. Dr. Axel Schambach, PhD
- Institute: Institute of Experimental Hematology, MHH
and
- PI(s): Prof. Dr. Armin Braun, Dr. Katherina Sewald
- Institute: Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM)
Towards better understanding and manipulation of tissue-resident αβ and γδ T lymphocytes in human lung tissue and lung-draining lymph nodes during end-stage lung diseases
- PI(s): Prof. Dr. Christine Falk
- Institute: Institut for Transplantation Immunology, MHH
and
- PI(s): Dr. Immo Prinz
- Institute: Institute of Immunology, MHH
Generating immunomodulatory macrophages for tissue repair and regeneration
- PI(s): Prof. Dr. Reinhold Förster, Dr. Swantje Hammerschmidt
- Institute: Institute of Immunology, MHH
and
- PI(s): Dr. Mania Ackermann
- Institute: Institute of Experimental Hematology, MHH
Analysis of cellular repair mechanisms and in vivo regeneration of the liver using optical techniques
- PI(s): Dr. Florian Vondran
- Institute: Clinic for Visceral surgery. MHH
and
- PI(s): Dr. Stefan Kalies
- Institute: Institute of Quantum Optics, LUH
Automated human iPSC macrophage production platform (iMAPP) for drug screening and tissue regeneration
- PI(s): Dr. Robert Zweigerdt
- Institute: Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG)/
Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe (LEBAO), MHH
and
- PI(s): Prof. Dr. Nico Lachmann
- Institute: Clinic for Pediatric Pneumology, Allergology and Neonatology (former: Exp. Hematology), MHH
Function of non-coding RNAs in Hepatic Stellate Cells during liver regeneration
- PI(s): PD Dr. Jan Fiedler
- Institute: Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) (former IMTTS)
and
- PI(s): Ingmar Mederacke
- Institute: Department of Gastroenterology, Hepatology and Endocrinology, MHH
Maximizing Kidney Regeneration by Reparative Cellular Senescence Reprogramming
- PI(s): Prof. Dr. Annette Melk, Prof. Dr. Rudolf Werner
- Institute: Department of Pediatric Kidney, Liver & Metabolic Diseases and Neuropediatrics. MHH
Investigation of astrocyte-microglia cross-talk during regeneration in the central nervous system
- PI(s): Dr. Martin Stangel
- Institute: Clinic for Neurology. MHH
and
- PI(s): Dr. Ulrich Kalinke
- Institute: Twincore, Zentrum für Experimentelle und Klinische Infektionsforschung
Imaging the Interface of Inflammation and Fibrosis in Progression and Treatment of Acute Myocardial Infarction and Ischemic Heart Failure: Molecular Imaging-Guided Precision Therapy
- PI(s): PD Dr. Jan Fiedler
- Institute: Institute: Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) (former IMTTS)
and
- PI(s): Prof. Dr. James Thackeray
- Institute: Nuclear medicine, MHH
Role of TPC and TRPML channels for extracellular vesicles release from cardiac macrophages in cardiac tissue repair and regeneration
- PI(s): Dr. Arndt Vogel, Dr. Anna Saborowski
- Institute: Department of Gastroenterology, Hepatology and Endocrinology, MHH
Biliary cells in liver regeneration and repair
- PI(s): Prof. Dr. Christian Wahl-Schott
- Institute: Institute for Neurophysiology. MHH
and
- PI(s): Filippo Perbellini
- Institute: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), MHH
